The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric simultaneous equations method for estimation of Betahistine Dihydrochloride and Prochlorperazine Maleate in Tablet Dosage Form. The method is based on the simultaneous equations for analysis of both the drugs using 0.1 N HCl as solvent. Betahistine Dihydrochloride has absorbance maxima at 261 nm and Prochlorperazine Maleate has absorbance maxima at 254 nm in 0.1 N HCl. The linearity was obtained in the concentration range of 4-25 �µg/ml and 4-22 �µg/ml for Betahistine Dihydrochloride and Prochlorperazine Maleate, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 98.75 �± 0.82 and 99.58 �± 0.16 for Betahistine Dihydrochloride and Prochlorperazine Maleate, respectively. The method was successfully applied to Tablet Dosage Form because no interference from the mixture excipients was found. The suitability of this method for the quantitative determination of Betahistine Dihydrochloride and Prochlorperazine Maleate was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Betahistine Dihydrochloride and Prochlorperazine Maleate in combination. The results of analysis have been validated statistically and by recovery studies.
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